Jonathan D Violin Selected Research

Sar-Arg-Val-Tyr-Ile-His-Pro-Ala-OH

3/2015	Heart failure therapeutics on the basis of a biased ligand of the angiotensin-2 type 1 receptor. Rationale and design of the BLAST-AHF study (Biased Ligand of the Angiotensin Receptor Study in Acute Heart Failure).
9/2013	First clinical experience with TRV027: pharmacokinetics and pharmacodynamics in healthy volunteers.
9/2012	TRV120027, a novel β-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure.
11/2011	Cardiorenal actions of TRV120027, a novel ß-arrestin-biased ligand at the angiotensin II type I receptor, in healthy and heart failure canines: a novel therapeutic strategy for acute heart failure.

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Jonathan D Violin Research Topics

Disease

7	Heart Failure 03/2015 - 10/2007
5	Pain (Aches) 01/2017 - 03/2013
2	Hyperalgesia 01/2019 - 01/2017
2	Acute Pain 01/2017 - 03/2014
2	Respiratory Insufficiency (Respiratory Failure) 09/2014 - 03/2014
1	Headache Disorders (Headache Syndromes) 01/2019
1	Secondary Headache Disorders 01/2019
1	Post-Traumatic Headache 01/2019
1	Migraine Disorders (Migraine) 01/2019
1	Chronic Pain 01/2017
1	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 07/2015
1	Hypertrophy 07/2015
1	Dyspnea (Shortness of Breath) 03/2015
1	Nausea 09/2014
1	Vomiting 09/2014
1	Hypercapnia 09/2014
1	Cardiovascular Diseases (Cardiovascular Disease) 10/2013
1	Cardiomegaly (Heart Hypertrophy) 09/2013
1	Reperfusion Injury 10/2012
1	Hypertension (High Blood Pressure) 10/2012
1	Flushing 05/2009
1	Dyslipidemias (Dyslipidemia) 05/2009
1	Myocardial Infarction 10/2007

Drug/Important Bio-Agent (IBA)

11	LigandsIBA 01/2017 - 10/2007
5	Morphine (MS Contin)FDA LinkGeneric 01/2019 - 03/2014
4	GTP-Binding Proteins (G-Protein)IBA 01/2017 - 05/2009
4	((3- methoxythiophen- 2- yl)methyl)((2- (9- (pyridin- 2- yl)- 6- oxaspiro(4.5)decan- 9- yl)ethyl))amineIBA 01/2017 - 03/2013
4	Sar-Arg-Val-Tyr-Ile-His-Pro-Ala-OHIBA 03/2015 - 11/2011
3	Opioid Analgesics (Opioids)IBA 01/2019 - 09/2014
3	Opioid Receptors (Opioid Receptor)IBA 01/2017 - 10/2013
3	sarcosine- arginyl- valyl- tyrosyl- lysyl- histidyl- prolyl- alanineIBA 07/2015 - 10/2012
3	ArrestinIBA 09/2013 - 11/2011
3	Angiotensin IIIBA 09/2013 - 11/2011
2	Pharmaceutical PreparationsIBA 09/2014 - 10/2007
2	Losartan (Cozaar)FDA LinkGeneric 09/2013 - 10/2012
1	4- (alpha- (4- allyl- 2,5- dimethyl- 1- piperazinyl)- 3- methoxybenzyl)- N,N- diethylbenzamideIBA 01/2019
1	Nitroglycerin (Dynamite)FDA LinkGeneric 01/2019
1	Tryptamines (Triptans)IBA 01/2019
1	Sumatriptan (Imigran)FDA LinkGeneric 01/2019
1	delta Opioid Receptors (delta Opioid Receptor)IBA 01/2019
1	Oxycodone (Oxycontin)FDA LinkGeneric 01/2017
1	Opioid Peptides (Opioid Peptide)IBA 01/2017
1	Fentanyl (Sublimaze)FDA LinkGeneric 01/2017
1	ArrestinsIBA 01/2017
1	mu Opioid Receptors (mu Opioid Receptor)IBA 01/2017
1	AngiotensinsIBA 07/2015
1	Cardiac MyosinsIBA 07/2015
1	Angiotensin Receptors (Angiotensin II Receptor)IBA 03/2015
1	Brain Natriuretic Peptide (Natrecor)FDA Link 03/2015
1	Analgesics (Analgesic Drugs)IBA 03/2014
1	AminesIBA 10/2013
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 10/2013
1	CalciumIBA 09/2013
1	SodiumIBA 09/2013
1	Furosemide (Lasix)FDA LinkGeneric 09/2012
1	Niacin (Nicotinic Acid)FDA LinkGeneric 05/2009
1	Vasodilator Agents (Vasodilators)IBA 05/2009
1	Prostaglandin D2IBA 05/2009
1	Nonesterified Fatty Acids (NEFA)IBA 05/2009
1	beta-ArrestinsIBA 05/2009
1	Phospholipases A2 (Phospholipase A2)IBA 05/2009
1	beta Adrenergic ReceptorsIBA 10/2007
1	Carvedilol (Coreg)FDA LinkGeneric 10/2007

Therapy/Procedure

4	Therapeutics 01/2017 - 10/2012
1	Length of Stay 03/2015
1	Patient Readmission 03/2015
1	Analgesia 09/2014